Ningetmy

• What Is A Political Ideology

DNA polymerase iota is an enzyme that in humans is encoded by the POLIgene.^[4] It is found in higher eukaryotes, and is believed to have arisen from a gene duplication from Pol η. Pol ι, is a Y family polymerase that is involved in translesion synthesis. It can bypass 6-4 pyrimidine adducts and abasic sites and has a high frequency of wrong base incorporation. Like many other Y family polymerases Pol ι, has low processivity, a large DNA binding pocket and doesn't undergo conformational changes when DNA binds. These attributes are what allow Pol ι to carry out its task as a translesion polymerase. Pol ι only uses Hoogsteen base pairing, during DNA synthesis, it will add adenine opposite to thymine in the syn conformation and can add both cytosine and thymine in the anti conformation across guanine, which it flips to the syn conformation.

Poli is the plural of polis. Polis is often translated as city, but there was a very important difference between an ancient Greek polis and a modern city. The ancient Greeks saw themselves as citizens of their poli no matter where they lived. If a person was born in Athens, he would consider himself an Athenian. Poli is a town and comune in Lazio, central Italy. It is located in the Monti Prenestini area. It is also the birthplace of Pope Innocent XIII and Cardinal Agostino Vallini.

What Is A Political Ideology

References[edit]

1. ^ ^abcGRCm38: Ensembl release 89: ENSMUSG00000038425 - Ensembl, May 2017
2. ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^Frank EG, Woodgate R (Aug 2007). 'Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese'. J Biol Chem. 282 (34): 24689–96. doi:10.1074/jbc.M702159200. PMID17609217.

Further reading[edit]

• McDonald JP, Tissier A, Frank EG, et al. (2001). 'DNA polymerase iota and related rad30-like enzymes'. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356 (1405): 53–60. doi:10.1098/rstb.2000.0748. PMC1087691. PMID11205331.
• Tissier A, Frank EG, McDonald JP, et al. (2001). 'Biochemical characterization of human DNA polymerase iota provides clues to its biological function'. Biochem. Soc. Trans. 29 (Pt 2): 183–7. doi:10.1042/BST0290183. PMID11356150.
• McDonald JP, Rapić-Otrin V, Epstein JA, et al. (1999). 'Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta'. Genomics. 60 (1): 20–30. doi:10.1006/geno.1999.5906. PMID10458907.
• Masutani C, Kusumoto R, Iwai S, Hanaoka F (2000). 'Mechanisms of accurate translesion synthesis by human DNA polymerase eta'. EMBO J. 19 (12): 3100–9. doi:10.1093/emboj/19.12.3100. PMC203367. PMID10856253.
• Tissier A, McDonald JP, Frank EG, Woodgate R (2000). 'poliota, a remarkably error-prone human DNA polymerase'. Genes Dev. 14 (13): 1642–50. PMC316739. PMID10887158.
• Tissier A, Frank EG, McDonald JP, et al. (2000). 'Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota'. EMBO J. 19 (19): 5259–66. doi:10.1093/emboj/19.19.5259. PMC302107. PMID11013228.
• Hartley JL, Temple GF, Brasch MA (2001). 'DNA cloning using in vitro site-specific recombination'. Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). 'Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs'. Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID11230166.
• Bebenek K, Tissier A, Frank EG, et al. (2001). '5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro'(PDF). Science. 291 (5511): 2156–9. doi:10.1126/science.1058386. PMID11251121.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). 'Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing'. EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC1083732. PMID11256614.
• Frank EG, Tissier A, McDonald JP, et al. (2001). 'Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template'. EMBO J. 20 (11): 2914–22. doi:10.1093/emboj/20.11.2914. PMC125476. PMID11387224.
• Vaisman A, Tissier A, Frank EG, et al. (2001). 'Human DNA polymerase iota promiscuous mismatch extension'. J. Biol. Chem. 276 (33): 30615–22. doi:10.1074/jbc.M102694200. PMID11402031.
• Ohmori H, Friedberg EC, Fuchs RP, et al. (2001). 'The Y-family of DNA polymerases'. Mol. Cell. 8 (1): 7–8. doi:10.1016/S1097-2765(01)00278-7. PMID11515498.
• Vaisman A, Woodgate R (2002). 'Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines'. EMBO J. 20 (22): 6520–9. doi:10.1093/emboj/20.22.6520. PMC125734. PMID11707422.
• Faili A, Aoufouchi S, Flatter E, et al. (2002). 'Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota'. Nature. 419 (6910): 944–7. doi:10.1038/nature01117. PMID12410315.
• Kannouche P, Fernández de Henestrosa AR, Coull B, et al. (2003). 'Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells'. EMBO J. 21 (22): 6246–56. doi:10.1093/emboj/cdf618. PMC137208. PMID12426396.
• Frank EG, Sayer JM, Kroth H, et al. (2002). 'Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota'. Nucleic Acids Res. 30 (23): 5284–92. doi:10.1093/nar/gkf643. PMC137958. PMID12466554.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). 'Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences'. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC139241. PMID12477932.